ok, not an SLK
but a 2001 S210. I went from the audio 10 to the audio 30 ( Becker) single din sat nav, ( no flip up screen). It was fine, integrated with the car's interior perfectly, and all the steering wheel controls worked as well. I did have to find the wire with the speed signal data in the passenger sill, tap into it, and run that to the block connector and connect it in there. I also had to route and mount the satellite antenna. Not that difficult all told, but fiddly.
I then upgraded that to a Becker Indianapolis, which despite similar looks and the same kind of integration, is a far superior unit, and it has a 3.5mm aux input capability. It does not have fibre -optic, so I lost the steering wheel button functions.
There would be no trouble getting either of these into an SLK, but you would probably have to find the speed signal and route the nav antenna. I'm pretty sure the audio 10 I had in mine had no GAL speed related volume function, which means there is no speed signal coming to it. Neither does the SLK have steering wheel control.